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- IHC Antibodies
- TNF-alpha IHC Antibody
TNF-alpha IHC Antibody
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Product Description
Description |
TNFα (Tumor Necrosis Factor alpha) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
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Catalog Number
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IW-PA1079 |
Quantity
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9 ml |
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Host
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Rabbit
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Clone
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Polyclonal
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Isotype
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IgG
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Immunogen
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A synthetic peptide corresponding to a sequence at the C-terminal of human TNFalpha, different from the related mouse sequence by five amino acids, and rat sequence by seven amino acids.
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Purity
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Immunogen affinity purified
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Conjugate
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Unconjugated
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Species Reactivity
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Human, mouse, rat.Not tested in other species. |
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Positive Control
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Human mammary cancer, colon cancer, rat brain
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Cellular Localization
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Cytoplasmic
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Form
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Ready to use solution in PBS with stabilizer and 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted.
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Storage
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Store at 2-8 °C. Do not freeze.
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Applications
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IHC-P: Heat induced epitope retrieval is required on formalin fixed paraffin sections. IHC-Tek Epitope Retrieval Solution (Cat# IW-1100) is recommended. IHC-Fr: Not tested. ICC: Not tested.
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Limitations
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This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.
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Precautions
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Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.
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References
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1. Shirai, T., Yamaguchi, H., Ito, H., Todd, C. W., Wallace, R. B. Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor.Nature 313: 803-806, 1985.
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