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alpha-SMA IHC Antibody

$258.00
SKU:
IW-MA1106
Quantity:

 

Product Description

Description

Ueyama et al. (1990) assigned the ACTSA gene to chromosome 10 by Southern blot analysis of DNAs from 18 rodent-human somatic cell hybrids. Regional mapping by in situ hybridization localized the gene to 10q22-q24.Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome .Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins.

 
Catalog Number

 

IW-MA1106

Quantity

 

9 ml

Host

 

Mouse

 

Clone

 

1A4

 

Isotype

 

Mouse IgG2a

 

Immunogen

 

N-terminal synthetic decapeptide of α-smooth muscle actin.

Purity

 

Purified by the goat anti-mouse IgG affinity chromatography.

Conjugate

 

Unconjugated

 

Species Reactivity

 

Human, mouse, rat. Not tested in other species.

Positive Control

 

Smooth muscle, colon, skin, tonsil.

Cellular Localization

 

Membrane/cytoplasmic

 

Form

 

Ready to use solution in PBS with stabilizer and 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted.

 

Storage

 

Store at 2-8 °C. Do not freeze.

 

Applications

 

IHC-P: Pretreatment is NOT required on formalin fixed paraffin sections.

IHC-Fr: Not tested.

ICC: Not tested.

 

Limitations

 

This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.

 

Precautions

 

Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.

 

References

 

1. Kumar, M. S.; Hendrix, J. A.; Johnson, A. D.; Owens, G. K. : Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins. Circ. Res. 92: 840-847, 2003.

2. Ueyama, H.; Bruns, G.; Kanda, N. : Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome 10. Jpn. J. Hum. Genet. 35: 145-150, 1990.

 

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