TH (Tyrosine hydroxylase) IHC Antibody

Product Description

Description	Tyrosine hydroxylase is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons.Human TH gene contains 13 primary exons and spans approximately 8 kb.TH is in the 11p15.5 region.
Catalog Number	IW-MA1100
Quantity	9 ml
Host	Mouse
Clone	TH-100
Isotype	Mouse IgG1
Immunogen	Rat tyrosine hydroxylase (TH).
Purity	Purified by the goat anti-mouse IgG affinity chromatography
Conjugate	Unconjugated
Species Reactivity	Human, rat. Not tested in other species.
Positive Control	Brain (striatum, substantia nigra)
Cellular Localization	Cytoplasmic of dopamine neurons
Form	Ready to use solution in PBS with stabilizer and 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted.
Storage	Store at 2-8 °C. Do not freeze.
Applications	IHC-P: Heat induced epitope retrieval is required on formalin fixed paraffin embedded sections. IHC-Fr: Formalin or acetone fixed frozen sections. ICC: Not tested.
Limitations	This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.
Precautions	Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.
References	1. Brilliant, M. H.; Niemann, M. M.; Eicher, E. M. : urine tyrosine hydroxylase maps to the distal end of chromosome 7 within a region conserved in mouse and man. J. Neurogenet. 4: 259-266, 1987. 2. Craig, S. P.; Buckle, V. J.; Craig, I. W.; Lamouroux, A.; Mallet, J. : Localization of the human tyrosine hydroxylase gene to chromosome 11p15. (Abstract) Cytogenet. Cell Genet. 40: 610 only, 1985. 3. Craig, S. P.; Buckle, V. J.; Lamouroux, A.; Mallet, J.; Craig, I. : Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways. Cytogenet. Cell Genet. 42: 29-32, 1986.