beta Amyloid Protein IHC Antibody

Product Description

Description	Beta amyloid protein is 4.2-kD polypeptide. Glenner and Wong(1984) purified a protein derived from the twisted beta-pleated sheet fibrils present in cerebrovascular amyloidoses and in the amyloid plaques associated with Alzheimer disease. The proteins from both disorders have an identical 28-amino acid sequence. memory deficits in middle-aged Tg2576 mice are caused by the extracellular accumulation of a 56-kDa soluble amyloid-beta assembly. Amyloid beta protein(Abeta) deposition in the brain is a hallmark of Alzheimer's disease(AD).
Catalog Number	IW-MA1109
Quantity	9 ml
Host	Mouse
Clone	AP-5
Isotype	Mouse IgG1
Immunogen	Synthetic β-amyloid peptide (1-40), conjugated to KLH.
Purity	Purified by the goat anti-mouse IgG affinity chromatography
Conjugate	Unconjugated
Species Reactivity	Human, mouse. Not tested in other species.
Positive Control	Alzheimer’s brain tissue
Cellular Localization	Extracellular senile plaque and neurofibrillary tangles
Form	Ready to use solution in PBS with stabilizer and 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted.
Storage	Store at 2-8 °C. Do not freeze.
Applications	IHC-P: Formic acid pretreatment or heat induced epitope retrieval (HIER) is required on formalin fixed paraffin embedded tissue sections. IHC-Fr: Not tested. ICC: Not tested.
Limitations	This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.
Precautions	Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.
References	1. Lesne, S.; Koh, M. T.; Kotilinek, L.; Kayed, R.; Glabe, C. G.; Yang, A.; Gallagher, M.; Ashe, K. H. : A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440: 352-357, 2006. 2. Lorenzo, A.; Yuan, M.; Zhang, Z.; Paganetti, P. A.; Sturchler-Pierrat, C.; Staufenbiel, M.; Mautino, J.; Vigo, F. S.; Sommer, B.; Yankner, B. A. : Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nature Neurosci. 3: 460-464, 2000.