Anti-SOCS3 Antibody (clone SO1) IHC-plus LS-B3317

Product Description

Presentation: PBS, pH 7.4, 0.09% sodium azide. Sourced in TCS.

Target Species: Human

Host Species: Mouse

Specificity: Recognizes suppressor of cytokine signaling 3 (SOCS3), a 30kD member of the suppressor of cytokine signaling family (SOCS) which negatively regulate Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways. SOCS3 specifically acts as a negative feedback regulator for the STAT3 pathways, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, thereby preventing the IL-6 activation of STAT3. The expression of SOCS3 is inducible by numerous factors, including IL-6, IL-10, Toll-like receptor (TLR) agonists and IFN gamma, making this protein the focus of research into inflammatory diseases, such as Arthritis, Colitis, and Crohns Disease. SOCS3 expression has also been shown to affect IFN alpha sensitivity in tumor studies.

Reactivity: Human

Usage: ELISA (1:100 - 1:500), IHC-P (10 g/ml), WB

Synonyms: SOCS3, Cish3, Cytokine-induced SH2 protein 3, CIS-3, CIS3, SSI-3, STAT-induced STAT inhibitor 3, SSI3, ATOD4, SOCS-3

Concentration: 1 mg/ml

Volume:

Immunogen: Full - length SOCS3 protein.