Specificity: Appears to recognize the human pre-synaptic protein, SNAP-25; an antigen of 26-27kD molecular weight. It will recognize SNAP-25 fusion protein from COS cells, but not with the fusion protein from bacterial systems. Research studies have used this antibody to study the distribution of synaptic changes in the hippocampus of patients with medically refractory temporal lobe epilepsy. (1., 3., 8.). Species cross-reactivity: rat, hamster and porcine.