Specificity: Recognizes the p53 - upregulated modulator of apoptosis (PUMA), also known as bbc3. PUMA is a pro-apoptotic member of the BCL-2 family. PUMA is localized to the mitochondria, binds BCL-2 and induces cytochrome C release and apoptosis in response to p53
Immunogen: Synthetic peptide ARARQEGSSPEPVEG corresponding to the N-terminus of human PUMA alpha. Percent identity by BLAST analysis: Human, Gibbon, Mouse, Rat, Porcine (100%); Opossum (87%).