Anti-IGF1R / IGF1 Receptor Antibody (clone 1H7) IHC-plus LS-B2613

Product Description

Presentation: PBS, pH 7.4, 0.09% sodium azide.

Target Species: Human

Host Species: Mouse

Specificity: Recognizes human CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to CD221

Reactivity: Human

Usage: Flo (1:10), IHC-P (10 g/ml), WB

Synonyms: IGF1R, CD221 antigen, CD221, IGF1 Receptor, IGFR, IGF-I receptor, Soluble IGF1R variant 1, Soluble IGF1R variant 2, Type 1 IGF receptor, IGFIR, JTK13

Concentration: 1 mg/ml

Volume:

Immunogen: