Specificity: Recognizes native, full-length human filamin (actin-binding protein) at 270-280kD and 190kD N-terminal calpain cleavage fragment of filamin. Following induction of apoptosis in U937 cells, recognizes 170, 150, and 120kD N-terminal cleavage fragments of the full-length from presumably resulting from cleavage by activated caspase-3. Species cross-reactivity: Chicken, guinea pig, rabbit and rat.
Reactivity: Chicken, Rabbit, Mouse, Guinea pig, Rat, Human