Anti-AICAR / ATIC Antibody (clone F38 P7 H9) IHC-plus LS-B7299

Product Description

Presentation: PBS, pH 7.4, 0.09% sodium azide. Sourced in TCS.

Target Species: Human

Host Species: Mouse

Specificity: Recognizes ATIC, otherwise known as AICAR, a ribonucleotide formyltransferase (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) and member of the purH family, which helps catalyze the final steps of the purine biosynthesis pathway. ATIC has been identified as an activator of AMP-activated protein kinase (AMPK), a known regulator of energy homeostasis, inhibitor of cell proliferation and inducer of apoptosis in cancerous cells of various origins, making ATIC a potential therapeutic agent for cancer. The anti-inflammatory and neuroprotective functions of ATIC, also have implications for its use in the treatment of Alzheimers disease.

Reactivity: Xenopus, Drosophila, Pig, Horse, Rabbit, Dog, Bovine, Human, Monkey

Usage: IHC-P (10 g/ml), WB

Synonyms: ATIC, AICAR, AICARFT, IMPCHASE, PURH

Concentration: 1 mg/ml

Volume:

Immunogen: Ovalbumin-conjugated synthetic peptide AHTNLRLFHH. Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Panda, Dog, Bovine, Horse, Rabbit, Pig, Xenopus, Drosophila, Beetle (100%); Mouse, Rat, Hamster, Bat, Opossum, Turkey, Chicken, Platypus, Stickleback, Mosquito (90%); Elephant, Salmon, Zebrafish, Seq squirt, Sea anemone, Ant, Nematode (80%).