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Anti-MYC / c-Myc Antibody (C-Terminus, clone 9E10) IHC-plus LS-B2791

$495.00
SKU:
LS-B2791
Quantity:

 

Product Description

  • Presentation: PBS, 15 mM sodium azide, approx., pH 7.4.

  • Target Species: Human

  • Host Species: Mouse

  • Specificity: The antibody 9E10 may be used to detect the c-Myc tag. The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells

  • Reactivity: Human

  • Usage: Flo (1 - 5 g/ml), IHC-P (10 g/ml), IP (1 - 5 g/ml), WB (0.5 - 2 g/ml)

  • Synonyms: MYC, BHLHe39, C-Myc, MRTL, Myc proto-oncogene protein, Proto-oncogene c-Myc, Rats1, Transcription factor p64, v-myc

  • Concentration: 1 mg/ml

  • Volume:

  • Immunogen: Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-myc. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Orangutan, Monkey, Marmoset, Tamarin (92%); Rat, Sheep, Hamster, Panda, Dog, Horse (85%).
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