Tau IHC Antibody

Description

The microtubule-associated proteins (MAPs) coassemble with tubulin into 
microtubules in vitro. Microtubule-associated protein tau appears to be
enriched in axons.Tau is composed of 352 to 441 amino acids. 
The isoforms differ from each other by the presence or absence of
29-amino acid or 58-amino acid inserts located in the N terminus and
a 31-amino repeat located in the C terminus. Tau is important in 
establishing and maintaining neuronal morphology and is a major 
component of the neurofibrillary tangles (NFTs) characteristic of 
Alzheimer's brain. Microtubule-associated protein tau (MTBT1) is 
mapped to chromosome 17q21.

Catalog Number

IW-MA1093

Quantity

9 ml

Host

Mouse

Clone

TAU-93

Isotype

Mouse IgG1

Immunogen

Bovine microtubule-associated proteins (MAPs).

Purity

Purified by the goat anti-mouse IgG affinity chromatography

Conjugate

Unconjugated

Species Reactivity

Human, mouse, rat. Not tested in other species.

Positive Control

Alzheimer’s brain tissue (neurofibrillary tangles, senile plaques)

Cellular Localization

Cytoplasmic

Form

Ready to use solution in PBS with stabilizer and 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted.

Storage

Store at 2-8 °C. Do not freeze.

Applications

IHC-P: Heat induced epitope retrieval is required on formalin fixed paraffin embedded sections.

IHC-Fr: Not tested.

ICC: Not tested.

Limitations

This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.

Precautions

Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.

References

1. Andreadis, A.; Brown, W. M.; Kosik, K. S. : Structure and novel exons of the human tau gene. Biochemistry 31: 10626-10633, 1992.

2. Donlon, T. A.; Harris, P.; Neve, R. L. : Localization of microtubule-associated protein tau (MTBT1) to chromosome 17q21. (Abstract) Cytogenet. Cell Genet. 46: 607, 1987.