TNFaIP1 IHC Antibody

Description

Tumor necrosis factor, alpha-induced protein 1 (endothelial), also known as TNFAIP1, is a human gene. The gene, present in single copy, was located in the 17q22-q23 region. ssThis gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. The protein is involved in the primary response

of the endothelium to TNF.

Catalog Number

IW-PA1305

Quantity

9 ml

Host

Rabbit

Clone

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminal of human TNFαIP1, identical to the related rat and mouse sequence.

Purity

Immunogen affinity purified

Conjugate

Unconjugated

Species Reactivity

Human, mouse, rat. Not tested in other species.

Positive Control

Rectal cancer

Cellular Localization

Nuclear

Form

Ready to use solution in PBS with stabilizer and 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted.

Storage

Store at 2-8 °C. Do not freeze.

Applications

IHC-P: Heat Induced Epitope Retrieval is required on formalin fixed paraffin embedded tissue sections.

IHC-Fr: Acetone fixed frozen sections.

ICC: Not tested.

Limitations

This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.

Precautions

Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.

References

1. Wolf, F. W.; Marks, R. M.; Sarma, V.; Byers, M. G.; Katz, R. W.; Shows, T. B.; Dixit, V. M.: Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene. J. Biol. Chem. 267: 1317-1326, 1992.